Pioneering NASA Astronaut Health Tech Thwarts Heart Failure

Prioritizing health is important on Earth, and it’s even more important in space. Exploring beyond the Earth’s surface exposes humans to conditions that can impact blood pressure, bone density, immune health, and much more. With this in mind, two NASA inventors joined forces 20 years ago to create a way to someday monitor astronaut heart health on long-duration spaceflight missions. This technology is now being used to monitor the health of patients with heart failure on Earth through a commercial product that is slated to launch in late 2024.

NASA inventors Dr. Rainee Simons, senior microwave communications engineer, and Dr. Félix Miranda, deputy chief of the Communications and Intelligent Systems Division, applied their expertise in radio frequency integrated circuits and antennas to create a miniature implantable sensor system to keep track of astronaut health in space. The technology, which was created at NASA’s Glenn Research Center in Cleveland with seed funds from the agency’s Technology Transfer Office, consists of a small bio-implanted sensor that can transmit a person’s health status from a sensor to a handheld device. The sensor is battery-less and wireless.

“You’re able to insert the sensor and bring it up to the heart or the aorta like a stent – the same process as in a stent implant,” Simons said. “No major surgery is needed for implantation, and operating the external handheld device, by the patient, is simple and easy.”

After Glenn patented the invention, Dr. Anthony Nunez, a heart surgeon, and Harry Rowland, a mechanical engineer, licensed the technology and founded a digital health medical technology company in 2007 called Endotronix, now an Edwards Lifesciences company. The company focuses on enabling proactive heart failure management with data-driven patient-to-physician solutions that detect dangers, based on the Glenn technology. The Endotronix primary monitoring system is called the Cordella Pulmonary Artery (PA) Sensor System. Dr. Nunez became aware of the technology while reading a technical journal that featured the concept, and he saw parallels that could be used in the medical technology industry.

The concept has proven to be an aid for heart failure management through several clinical trials, and patients have experienced improvements in their quality of life. Based on the outcome of Endotronix’s clinical testing to demonstrate safety and effectiveness, in June 2024 the U.S. Food and Drug Administration granted premarket approval to the Cordella PA Sensor System. The system is meant to help clinicians remotely assess, treat, and manage heart failure in patients at home with the goal of reducing hospitalizations.

“If you look at the statistics of how many people have congestive heart failure, high blood pressure… it’s a lot of people,” Miranda said. “To have the medical community saying we have a device that started from NASA’s intellectual property – and it could help people worldwide to be healthy, to enjoy life, to go about their business – is highly gratifying, and it’s very consistent with NASA’s mission to do work for the benefit of all.”

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Controlled Propulsion for Gentle Landings 

The Curiosity and Perseverance Mars rovers continue to provide a wealth of information about the Red Planet. This was made possible in part by the sky crane landing systems that safely lowered them to the planet’s surface. Their successful descent, managed by eight powerful engines, depended on one small part – a valve. 

The engines produced about 750 pounds of thrust each, so they required more fuel than a conventional valve could deliver, said Carl Guernsey, propulsion subsystem chief engineer for the Mars Sample Laboratory Mission. 

“With the engines pointing down, we throttle up and increase the thrust, so we slow down,” said Guernsey. “At a certain altitude above the surface, you hold at a constant velocity to collect more sensor data, and then proceed with the rest of the descent.”  

With only seconds for sensor data to identify the landing area and direct any last-minute diversion maneuvers, landing requires fuel available at the right time. To build the valve to help accomplish this task, NASA turned to a company that has provided the space program with reliable gas regulators since the 1950s. Through a series of mergers, by 2021, the original company, called Conax Florida, became part of Eaton based in Orchard Park, New York.  

Working under contract with NASA’s Jet Propulsion Laboratory in Southern California, the company developed a new one-time-use pyrovalve to sit between the hydrazine fuel tank and engines. The zero-leak valve was the largest ever made of its type at the time, at three-fourths of an inch. 

The Y-shaped pipe with a pair of leak-proof solid metal barriers prevented propellant from flowing. The valve contains a pyrotechnic charge that activates a piston called a flying ram, which shears off the barriers, allowing fuel to flow. But a problem arose during flight qualification testing. Sometimes the ram didn’t stay wedged in place at the bottom, posing a blockage risk. 

The solution the team came up with had never been tried before – magnets at the bottom of the valve. But the successful Perseverance landing in 2021 proved it works. The same valve is included in the Perseverance rover and now enables commercial rocket-stage separation in space. 

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Program Executive Dr. Yaítza Luna-Cruz

“My mom had to leave school after 9th grade to support her family, but she always emphasized the importance of education. And with a lot of sacrifices, got us an encyclopedia in Spanish, ‘Enciclopedia de Las Ciencias’. By getting that encyclopedia for us, without knowing it, my mom was my first mentor because she introduced me to science. So that’s what helped fall in love with physics.

“I was the first of many things. I was the only one in my whole class that decided to study physics at the University of Puerto Rico at Mayagüez. I was the first master student to do a thesis related to atmospheric physics. There was no atmospheric sciences and meteorology in Puerto Rico, I saw the need and potential, so I started the first student chapter of the American Meteorological Society in Puerto Rico. I was the first one to get a PhD in atmospheric physics from the program and there have been so many firsts since then. 

“I’m leading by example. I don’t want the people who look like me to experience what I experienced because I was alone many times. And there’s a saying that says you cannot be what you can’t see.

“So, I’m not just doing science. I’m doing Science with Purpose, and my purpose is to be the voice for those who are underrepresented in science, open doors and opportunities and help them understand that they have a space in science.”

– Dr. Yaíta Luna-Cruz, Program Executive, Earth Science Division, NASA Headquarters

Image Credit: NASA/Keegan Barber
Interviewer: NASA/Jessica Salani

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Hubble Spots a Grand Spiral of Starbursts

The sparkling scene depicted in this NASA/ESA Hubble Space Telescope image is of the spiral galaxy NGC 5248, located 42 million light-years from Earth in the constellation Boötes. It is also known as Caldwell 45. The Caldwell catalog holds visually interesting celestial objects that are not as commonly observed by amateur astronomers as the more famous Messier objects.

NGC 5248 is one of the so-called ‘grand design’ spirals, with prominent spiral arms that reach from near the core out through the disk. It also has a faint bar structure at its center, between the inner ends of the spiral arms, which is not quite so obvious in this visible-light portrait from Hubble. Features like these which break the rotational symmetry of a galaxy have a huge influence on how matter moves through it, and eventually its evolution through time. They feed gas from a galaxy’s outer reaches to inner star-forming regions, and even to a galaxy’s central black hole where it can kick-start an active galactic nucleus.

These flows of gas have shaped NGC 5248 in a big way; it has many bright ‘starburst regions’ of intense star formation spread across its disk, which a population of young stars dominates. The galaxy even has two very active, ring-shaped starburst regions around its nucleus, filled with young clusters of stars. These ‘nuclear rings’ are remarkable enough, but normally a nuclear ring tends to block gas from getting further into the core of a galaxy. NGC 5248 having a second ring inside the first is a marker of just how forceful its flows of matter and energy are! Because the galaxy is relatively nearby, its highly visible starburst regions make the galaxy a target for professional and amateur astronomers alike.

Media Contact:

Claire Andreoli
NASA’s Goddard Space Flight Center, Greenbelt, MD
claire.andreoli@nasa.gov

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