Complement-ARIE NAMs Reduction to Practice Challenge

Complement-ARIE NAMs Reduction to Practice Challenge

Recent technological advances have set the stage for a renewed focus on human-based solutions called new approach methodologies (NAMs) that can complement, and in some cases replace, animal models in research and regulatory testing. These NAMs generally span advanced cell-tissue-organoid (in vitro), computational modeling (in silico), and cell-free biochemical analysis (in chemico) techniques, with each type of NAM offering different advantages. A combination and integration of multiple NAMs elements into a synergistic approach that augments gaps and/or deficiencies in individual NAMs approaches is a “combinatorial NAM” and could ultimately allow for improved predictions of human clinical response. Although many combinatorial NAMs are still early in development, not validated and standardized, nor available to the market broadly, combinatorial NAMs can potentially transform the way biomedical research, drug development, and clinical trials are conducted. To accelerate development and validation of combinatorial NAMs for human-based scientific and regulatory purposes, the National Institutes of Health (NIH) Common Fund’s Complement-Animal Research In Experimentation (Complement-ARIE) program in collaboration with the Food and Drug Administration (FDA) and Environmental Protection Agency (EPA), is launching the Reduction to Practice (RTP) Challenge. This challenge invites innovative combinatorial NAMs solutions from multidisciplinary teams who can successfully demonstrate implementation of their human-based solution in a practical and usable form within a 3-year period. Solvers will have the chance to win up to $1,430,000 in cumulative cash prizes and have their solution provided validation and/or qualification support by the Complement-ARIE Validation and Qualification Network (VQN). This Challenge is open to the public. 

Award: $7,000,000 in total prizes

Open Date: Phase 1 – September 30, 2025, Phase 2 – July 2, 2026; Phase 3 – August 1, 2027

Close Date: Phase 1 – March 1, 2026

For more information, visit: https://www.herox.com/Complement-ARIE-RTP

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Sarah Douglas

NASA Bolsters Golden Age of Exploration with Technology Priorities

NASA Bolsters Golden Age of Exploration with Technology Priorities

3 min read

Preparations for Next Moonwalk Simulations Underway (and Underwater)

Graphic for the cover of NASA's Fiscal Year 2025 budget request, showing an artist's view of the Earth's horizon and atmosphere from space, the Moon, Mars and a field of stars.
NASA

As NASA prepares for long-duration missions to the Moon that will pave the way for human exploration on Mars, the agency is tapping into America’s expanding space economy to help guide its strategic technology investments. This initiative, led by NASA’s Space Technology Mission Directorate invites collaboration from U.S. industry leaders, academic institutions, and other government agencies to help prioritize critical technology development needs – known as shortfalls – identified for future science and exploration missions. 

“NASA wants to hear directly from the nation’s brightest minds to drive solutions for our greatest technology needs as we lead America’s exploration through the solar system,” said Greg Stover, acting associate administrator for NASA’s Space Technology Mission Directorate (STMD) at NASA Headquarters in Washington. “As we pursue collaboration with industry to support our most ambitious missions and increase agility, prioritizing NASA’s technology efforts ensures the most efficient and impactful progress for the agency and its stakeholders.” 

Until Friday, Feb. 20, NASA will collect input from the aerospace community on consolidated technology shortfalls, such as developing infrastructure and capabilities for long-term operations in the lunar and Martian environments. Technology stakeholders will participate in virtual meetings, provide feedback, and submit their shortfall ranking to the agency.

This effort builds on NASA’s first shortfall ranking exercise in 2024 which asked participants to rank 187 civil space shortfalls, resulting in an integrated list of technology priorities. Based on the invaluable feedback provided by stakeholders in the first exercise, NASA has streamlined the process by consolidating the shortfalls into 32 broader, integrated categories, each addressing specific needs to provide further definition and context. This restructuring maintains the original content’s depth while creating a more efficient and accessible feedback mechanism for participants. 

NASA will analyze and aggregate the rankings to produce priority lists for each stakeholder group, which will be made publicly available for continued collaboration. This prioritization framework will guide NASA’s evaluation of current technology development efforts to identify necessary adjustments within its existing portfolios.

The shortfall prioritization process may inspire new investments within NASA or spark innovative partnerships with external stakeholders. This initiative also has the potential to unlock emerging commercial opportunities and accelerate growth in the U.S. space economy.

As NASA nears its next mission to the Moon, prioritizing the most important and impactful efforts helps NASA appropriately direct available resources to best support mission needs for the agency and the nation. To maintain this collaborative approach, STMD plans to conduct feedback sessions and workshops every three years with industry, academia, and other government agencies, creating a dynamic process that continuously incorporates stakeholder insights and end-user perspectives.

The agency remains committed to refining this engagement framework, ensuring it delivers maximum value to all participants while advancing America’s leadership in space exploration and technology development.

To review the list of technology shortfalls and add input to NASA Space Technology’s prioritization effort, visit:

https://www.nasa.gov/spacetechpriorities

By: Jasmine Hopkins

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Jan 12, 2026

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Loura Hall

Hubble Spies Stellar Blast Setting Clouds Ablaze

Hubble Spies Stellar Blast Setting Clouds Ablaze

2 min read

Hubble Spies Stellar Blast Setting Clouds Ablaze

Narrow, knotted clouds of purple and green glowing gas are seen against a field of stars.
Jets of ionized gas streak across a cosmic landscape from a newly forming star.
NASA, ESA, and B. Reipurth (Planetary Science Institute); Processing: Gladys Kober (NASA/Catholic University of America)

This new NASA Hubble Space Telescope image captures a jet of gas from a forming star shooting across the dark expanse. The bright pink and green patches running diagonally through the image are HH 80/81, a pair of Herbig-Haro (HH) objects previously observed by Hubble in 1995. The patch to the upper left is part of HH 81, and the bottom streak is part of HH 80.

Herbig-Haro objects are bright, glowing regions that occur when jets of ionized gas ejected by a newly forming star collide with slower, previously ejected outflows of gas from that star. HH 80/81’s outflow stretches over 32 light-years, making it the largest protostellar outflow known. 

Protostars are fed by infalling gas from the surrounding environment, some of which can be seen in residual “accretion disks” orbiting the forming star.  Ionized material within these disks can interact with the protostars’ strong magnetic fields, which channel some of the particles toward the pole and outward in the form of jets. 

As the jets eject material at high speeds, they can produce strong shock waves when the particles collide with previously ejected gas. These shocks heat the clouds of gas and excite the atoms, causing them to glow in what we see as HH objects.

HH 80/81 are the brightest HH objects known to exist. The source powering these luminous objects is the protostar IRAS 18162-2048. It’s roughly 20 times the mass of the Sun, and it’s the most massive protostar in the entire L291 molecular cloud. From Hubble data, astronomers measured the speed of parts of HH 80/81 to be over 1,000 km/s, the fastest recorded outflow in both radio and visual wavelengths from a young stellar object. Unusually, this is the only HH jet found that is driven by a young, very massive star, rather than a type of young, low-mass star. 

The sensitivity and resolution of Hubble’s Wide Field Camera 3 was critical to astronomers, allowing them to study fine details, movements, and structural changes of these objects. The HH 80/81 pair lies 5,500 light-years away within the Sagittarius constellation.

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Media Contact:

Claire Andreoli
NASA’s Goddard Space Flight CenterGreenbelt, MD
claire.andreoli@nasa.gov

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Susan Schuh: Supporting the Humans in Human Spaceflight 

Susan Schuh: Supporting the Humans in Human Spaceflight 

Susan Schuh has dedicated her career to helping humans adapt to life beyond Earth.  

As the Flight Crew Integration Operational Habitability (OpsHab) team lead in NASA’s Human Health and Performance Directorate at Johnson Space Center in Houston, Schuh leads efforts to understand what it is really like to live and work in space. She turns that information into progress by documenting astronauts’ feedback to improve current and future spaceflight missions. 

A woman wears a colorful blouse and poses in front of a blue background and a NASA flag (right) and U.S. flag (left).
Official portrait of Susan Schuh.
NASA/Josh Valcarcel

Her work not only supports crews aboard the International Space Station, but also provides critical information for NASA’s preparations to explore more of the lunar surface than ever before through Artemis missions.  

Her team supports astronaut inflight and postflight debriefs, capturing and analyzing feedback to help NASA apply lessons learned. They also manage one of NASA’s most valuable habitability tools, the Crew Comments Database. With more than 115,000 entries spanning 25 years of International Space Station missions, it is the only comprehensive and searchable record of crew feedback in existence. Every comment, from how astronauts sleep to how they organize supplies, becomes part of NASA’s collective learning. 

“The Crew Comments Database is my work pride and joy,” Schuh said. “It’s been an invaluable resource for operations and development and continues to lend itself to future exploration.” 

Schuh’s path to NASA began with a mentor who saw her potential early on. While studying psychology at Flagler College in St. Augustine, Florida, she was introduced to human factors research by Dr. Gerald Gamache, whose work on the effects of the Chernobyl reactor explosion helped shape her understanding of how people function in complex environments.  

While completing her master’s degree in human factors and systems at Embry-Riddle Aeronautical University in Daytona Beach, Florida, Schuh began her first internship at NASA in 2000. “Even from the first days of my internship at Johnson, I knew I was meant to be a part of this community supporting humans living and working in space,” she said.  

Schuh left Johnson briefly to support human systems integration for the Navy and Air Force but returned in 2006. Since then, she has continued to shape how astronauts experience living and working in space. 

A group of people pose in an auditorium in front of a blue background with a NASA meatball insignia.
NASA astronauts and panelists participate in the Parent Support Panel Discussion at NASA’s Johnson Space Center. Johnson Employee Assistance Program counselor Anika Isaac, top left, moderated the event alongside Susan Schuh, second from left, top row. Author Emily Oster, front center, joined astronaut parents, from left, Christina Koch, Jessica Watkins, Jessica Meir, and Reid Wiseman.
NASA/David DeHoyos

Her mentor’s influence extended beyond Schuh’s technical work. “Dr. Gamache was also a community builder outside of his professional life, and I’d like to think some of that rubbed off on me,” she said. That inspiration led her to found the Johnson Parenting community in 2020, which now includes more than 600 members who share support and resources for working parents across the center. 

Schuh has learned that her work is about more than data—it is about people. “Being purposeful in taking time to listen and be willing to learn and collaborate has made all the difference for me,” she said. “Over time, I’ve learned a lot about perseverance. This work has required it, encouraging folks to utilize the Crew Comments Database and keeping the feedback process empowered and robust.” 

A woman poses with her daughter after accepting an award.
Susan Schuh is honored with a Space Flight Awareness Silver Snoopy award on March 24, 2022. She is pictured with her daughter, Lorelei.
NASA/Robert Markowitz

She is most proud of her family, known as Team Schuh—her husband, Scott, who works on the Orion Ascent Abort Mode Team, and their three daughters, Wilhelmina, Lorelei, and Franny. “They’re the reason I keep striving to balance work, family, and everything in between,” she said.  

Finding that balance has been an ongoing struggle for her. “One of my biggest professional challenges, especially in the last 14 years since my oldest daughter was born, has been finding work-life balance,” she said. “I often struggle with creating boundaries and calling it a day at a reasonable time. I won’t pretend I have the secret recipe, but I’m working on it for sure.” Schuh credits the Johnson Parenting community for helping her and others along the way. 

A family of four stands in front of nature and a waterfall.
Susan Schuh with her husband, Scott, and their three daughters, Wilhelmina, Lorelei, and Franny.

Outside of work, Schuh finds peace in the water and in nature. Her father, who worked in underwater engineering, taught her to scuba dive when she was 11. “We’ve taken some amazing multi-day trips together, including multiple visits to Cay Sal Bank,” she said. “He’s my favorite dive buddy, and I look forward to many more dive trips with him.” 

Looking ahead, Schuh hopes to pass on that same sense of purpose she has found at NASA to the next generation. “Make connections and nurture them. It’s always cool to be kind,” she said. “Stay true to yourself and your values. Tell the people you admire how and why they inspire you.” 

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Sumer Loggins

Change of Command of International Space Station to Occur

Change of Command of International Space Station to Occur

This long-exposure photograph from the International Space Station was taken 263 miles above the Indian Ocean at approximately 11:02 p.m. local time. The image reveals clouds stretching into a soft blur beneath the orbital outpost, a bright airglow blanketing Earth’s horizon, and faint star trails arcing across the night sky. The SpaceX Dragon cargo spacecraft is visible in the lower foreground, framed by a window aboard the SpaceX Dragon crew spacecraft.
This long-exposure photograph from the International Space Station was taken 263 miles above the Indian Ocean at approximately 11:02 p.m. local time. The image reveals clouds stretching into a soft blur beneath the orbital outpost, a bright airglow blanketing Earth’s horizon, and faint star trails arcing across the night sky. The SpaceX Dragon cargo spacecraft is visible in the lower foreground, framed by a window aboard the SpaceX Dragon crew spacecraft.
NASA

NASA will provide live coverage of the International Space Station change of command ceremony starting at 2:35 p.m. EST Monday, Jan. 12. on NASA+, Amazon Prime, and the agency’s YouTube channel. As Crew-11 prepares to depart from the space station, NASA astronaut Mike Fincke will hand command of Expedition 74 aboard the orbital complex to Roscosmos cosmonaut Sergey Kud-Sverchkov.

Following Crew-11’s departure on Wednesday, Jan. 14, NASA astronaut Zena Cardman and Fincke, JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui, and Roscosmos cosmonaut Oleg Platonov will splash down off the coast of California at approximately 3:40 a.m. on Thursday, Jan. 15. NASA and SpaceX are reviewing weather conditions in the splashdown zones, which currently are favorable for return.

On Jan. 8, NASA announced its decision to return the agency’s SpaceX Crew-11 mission to Earth from the space station earlier than originally planned as teams monitor a medical concern with a crew member currently living and working aboard the orbital laboratory, who is stable. Due to medical privacy, it is not appropriate for NASA to share more details about the crew member. 

NASA will share more details about its coverage plans in the coming days.

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Joseph Zakrzewski