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Thanksgiving week starts with the Expedition 61 crew exploring the stresses microgravity imposes on organisms at the cellular level. The International Space Station is also ramping up for cargo traffic and another spacewalk in December.

The astronauts in the U.S. segment of the orbiting lab focused their attention today on identifying the cellular changes caused by weightlessness. Observations may provide doctors with advanced therapeutic insights into diseases afflicting humans on Earth and ailments that affect astronauts in space.

Two more spacewalks are scheduled to service an astrophysics device, the Alpha Magnetic Spectrometer (AMS), searching for clues to the origin of the universe. Astronauts Andrew Morgan and Luca Parmitano will continue the complex work on Monday, Dec. 2 at 6:50 a.m. EST to replace the AMS thermal control system.

Russia’s Progress 73 cargo craft will compete its 121-day mission attached to the Pirs docking compartment this Friday and undock for a fiery disposal above the south Pacific. It will be replaced when the Progress 74 resupply ship launches Dec. 6 and docks to Pirs on Dec. 8.

SpaceX is targeting Dec. 4 for the launch if its 19^th commercial cargo mission to the space station. The Dragon space freighter would arrive on Dec. 7 delivering a variety of brand new research gear including Japan’s Hyperspectral Imager Suite, or HISUI.

Expedition 61 Commander Luca Parmitano of ESA (European Space Agency) and NASA Flight Engineer Andrew Morgan concluded their spacewalk at 1:35 p.m. EST. During the six-hour and 33-minute spacewalk, the two astronauts successfully cut a total of eight stainless steel tubes, including one that vented the remaining carbon dioxide from the old cooling pump. The crew members also prepared a power cable and installed a mechanical attachment device in advance of installing the new cooling system.

Today’s work clears the way for Parmitano and Morgan’s next spacewalk in the repair series Monday Dec. 2. The plan is to bypass the old thermal control system by attaching a new one off the side of AMS during the third spacewalk, and then conduct leak checks on a fourth spacewalk.

For more on the AMS science and spacewalks, listen to the recent podcasts:

• Houston We Have a Podcast Ep 117: Alpha Magnetic Spectrometer: The Science
• Houston We Have a Podcast Ep 118: Alpha Magnetic Spectrometer: The Spacewalks
• Houston We Have a Podcast Ep 119: Alpha Magnetic Spectrometer: The Tools

Space station crew members have conducted 223 spacewalks in support of assembly and maintenance of the orbiting laboratory. Spacewalkers have now spent a total of 58 days 9 hours and 41 minutes working outside the station. Parmitano has now conducted three spacewalks in his career and Morgan has now logged four spacewalks since his arrival on the station in July.

Keep up with the crew aboard the International Space Station on the agency’s blog, follow @ISS on Instagram, and @space_station on Twitter.