Tech Today: Synthetic DNA Diagnoses COVID, Cancer

Tech Today: Synthetic DNA Diagnoses COVID, Cancer

2 min read

Preparations for Next Moonwalk Simulations Underway (and Underwater)

Princeton University undergraduate Kate Sheldon in a lab, holding a rectangular device in both hands
Princeton University undergraduate Kate Sheldon, doing summer work at Firebird Diagnostics, holds a prototype of the Agnostic Life Finder, or ALF, which was developed to seek life on Mars without making Earth-specific assumptions about molecular biology.
Credit: Firebird Diagnostics LLC

At first glance, the search for life beyond Earth might not seem related to human illness, but to biochemist Steven Benner, the connection is clear.

“In diagnostics for an infectious disease, you’re looking for alien life inside of a patient,” said Benner, who has spent nearly two decades conducting NASA-funded research on what alien life might look like at the molecular level.

“It’s actually a bit easier to build a diagnostics assay to detect COVID than to build an agnostic life finder to search for Martian DNA, whose structure would be unknown,” he said.

Benner is the co-founder and CEO of Firebird Diagnostics LLC, based in Alachua, Florida, which sells synthetic DNA and molecule packages to researchers, who use them to develop tools to detect and treat ailments like cancer, hepatitis, and HIV. The company also sold COVID tests during the pandemic.

Benner holds that while some of what we know about biochemistry on Earth may be universal, most is Earth-specific. He and his partners developed DNA-like molecular systems with six and eight nucleotides, or building blocks, based on research funded partly by NASA’s Astrobiology Program. These systems add to the four building blocks in Earth-based DNA an additional two or four synthetic nucleotides.

Mary Voytek, head of the Astrobiology Program at NASA Headquarters in Washington, said Benner’s work shows there are alternatives to Earth-based biological molecules, “This helps us understand what else is possible and may be found in life beyond Earth.”

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Apr 04, 2024

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Andrew Wagner

NASA Wallops to Launch Three Sounding Rockets During Solar Eclipse 

NASA Wallops to Launch Three Sounding Rockets During Solar Eclipse 

Three Black Brant IX sounding rockets for the Atmospheric Perturbations around Eclipse Path (APEP) mission are scheduled to launch from NASA’s Wallops Flight Facility launch range in Virginia. The launch window opens April 8, 2024, at 2:40 p.m. EDT.  

Launching approximately 45 minutes before, during, and after the peak local eclipse, the APEP sounding rockets will study how Earth’s upper atmosphere is affected when sunlight momentarily dims over a portion of the planet. Targeted launch times for the three rockets are 2:40 p.m., 3:20 p.m., and 4:05 p.m. but may be subject to change. 

The launches will be livestreamed on Wallops’ YouTube beginning at 2:30 p.m.  

Weather permitting, the launches may be visible in the mid-Atlantic region. Remember to always wear solar safety or “eclipse” glasses when looking at the Sun to protect your eyes. For the Wallops area, the eclipse will begin around 2:06 p.m. The Moon will block 81.4% of the Sun’s light at peak local eclipse at 3:23 p.m. and conclude at 4:34 p.m. 

A visibility map showing the mid-Atlantic region. The map shows how many seconds after that people in the area may be able to see the Black Brant IX sounding rocket in the sky.  The land is green and the ocean is dark blue. Visibility of 30-42 seconds is represented by a bright pink semi-circile reaching up to eastern Massachusetts, through most of Pennsylvania, through eastern West Virginia, Virginia and North Carolina. Visibility area for viewers with a line-of-sight 10-30 seconds after launch is a blue semi-circle reaching from middle of New Jersey down to north North Carolina and inland to Virginia. Visibility from 0-10 seconds is indicated by a bright green semi-circle mostly covering to the edge of the southern border of Delaware and down into the Eastern Shore of Virginia. City labels starting north at Trenton, Philadelphia, Dover, Baltimore, Washington, Pittsburgh, Charlottesville, Richmond, and Raleigh. On the right is a black box with white words: "Colors indicate when viewers will have line-of-sight access to the vehicle, with 3° elevation or more. Measured in seconds after takeoff.
Launch viewing map forAtmospheric Perturbations around Eclipse Path mission are scheduled to launch from NASA’s launch range at Wallops Flight Facility in Virginia on April 8, 2024.
Credit: NASA

Members of the public are invited to the NASA Wallops Visitor Center on Monday, April 8, to view the sounding rocket launches and the partial eclipse. Gates to the visitor center will open from 1-5 p.m. and will close once parking lot capacity is reached. For those traveling to our visitor center, all vehicles MUST fit within a standard parking spot for this event; no large, oversized vehicles or buses will be allowed for entry. 

The visitor center will offer solar-related activities, have NASA sounding rocket experts onsite to answer questions, and host Globe Program expert Brian Campbell, who will be showing people how to collect data during the eclipse using the Observer app. Eclipse glasses and pinhole viewers will be available during this event while supplies last. Food trucks will be onsite serving food and drinks, including empanadas, crab cakes, hamburgers, hot dogs, barbecue, water ice, and more. 

While this combined viewing event is exciting for some, it may not be ideal for all. A designated sensory-friendly quiet area will be available at the Wallops Visitor Center for guests. This supervised quiet area will include dimmed lighting, seating, a reflection area, and touch items for guests to explore. 

Prepare for safe solar viewing during this year’s eclipse by checking out NASA’s Eclipse Safety page. 

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Amy Barra 
NASA’s Wallops Flight Facility, Wallops Island, Virginia

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Madison Olson

Advances in Understanding COPV Structural Life 

Advances in Understanding COPV Structural Life 

The Structures Technical Discipline Team (TDT) was involved in numerous investigations this past year, but composites, fracture mechanics, and pressure vessels dominate the list. All three of these specialties are important to composite overwrapped pressure vessels (COPV). One of the TDT’s most important findings this year was the exposure of an inherent vulnerability that underpredicts structural life, driven by current specifications and testing standards for COPVs. This NESC work and its recommendations will significantly improve safety and mission success for all current and future COPV operations throughout the aerospace community. 

Dr. David Dawicki employs digital image correlation to evaluate strain in metallic coupons. 

Damage Tolerance Analysis Standard Can Be Unconservative for COPVs 

COPVs consist of a metallic liner that contains the fluid or gas and a composite overwrap that provides strength (Figure 1). The operational pressure cycles for a spaceflight COPV generally starts with an initial overpressure, called an autofrettage cycle, that yields the metallic liner, while the stronger composite overwrap remains elastic. Liner yielding during autofrettage results in a small amount of liner growth, resulting in liner compression when the COPV is depressurized after autofrettage. The subsequent operational cycles can be either elastic (elastically responding COPV) or elastic-plastic (plastically responding COPV).

  Figure 1.Illustration of COPV major components.

The damage tolerance life evaluation of spaceflight COPVs is governed by the ANSI/AIAA-S-081B, Space Systems–Composite Overwrapped Pressure Vessels. This standard provides the baseline requirements for damage tolerance analyses (DTA) of COPVs with elastically responding liners. The standard allows the DTA to consider the influence of the elastic-plastic autofrettage cycle independently of the elastically responding cycles. The elastically responding cycles are permitted to be analyzed using linear elastic fracture mechanics (LEFM) tools like the NASGRO crack-growth analysis software. The standard states that the DTA must not consider any beneficial influences of the autofrettage cycle on the subsequent elastically responding cycles but does not consider the possibility of detrimental influences of the autofrettage cycle.  

In the study, Unconservatism of Linear-Elastic Fracture Mechanics Analysis Post Autofrettage (NASA/TM-20230013348), an NESC team conducted a combined experimental and analytical investigation into the influence of the autofrettage cycle on subsequent elastic cycles. Tests were conducted on coupons with part-through surface cracks that were subjected to cyclic loading that was representative of the operational cycles of a COPV liner. Half of the tests were conducted with the full loading history (including the autofrettage cycle) and the other half were identical except that the autofrettage cycle was omitted. Cracks in the tests with the autofrettage cycle grew faster than cracks in the identical tests that excluded the autofrettage cycle, as shown by the fracture surfaces in the photomicrographs (Figure 2). The distance between the mark left by the autofrettage cycle and the ductile fracture region was the amount of crack growth (Δa=0.0077 inch) due to the LEFM cycles. Crack growth due to the LEFM cycles in the LEFM-only test was Δa=0.0022 inch, more than three times slower than that in the identical autofrettage plus LEFM test. 


Figure 2. Fracture surfaces from two identical tests showing crack growth (Δa), with and without an initial autofrettage cycle. 

A validated finite element analysis and experimental measurements were used to evaluate the influence of the autofrettage cycle. The elastic-plastic autofrettage cycle was found to create a large region of plastic deformation ahead of the crack and blunted the crack tip. Previous fracture mechanics tests and analytical studies in the literature examined elastic overloads and found that plastic deformation ahead of the crack developed residual stresses that closed the crack surfaces, reducing the subsequent crack growth rate. However, the crack blunting allowed the crack to remain open for the entire loading, as illustrated by the finite element simulations of the crack surfaces at peak and minimum stress (Figure 3). The differences between the tests with and without the autofrettage cycle that were observed experimentally and simulated with a validated finite element analysis indicate that the damage tolerance analysis approach allowed by the standard can be unconservative. The NESC proposed an alternative damage tolerance analysis approach and recommended that the AIAA Aerospace Pressure Vessel Committee on standards update the ANSI/AIAA S-081B standard to address COPV liners with compressive stresses following the peak autofrettage stress.

 
Figure 3. Abaqus finite element analysis of crack growth with and without an autofrettage cycle. Y-axis indicates crack opening displacement and x-axis indicates crack length.

A Brief Introduction to Damage Tolerance for COPVs 

ANSI/AIAA S-081B standard, Space Systems–Composite Overwrapped Pressure Vessels, is a compilation of accepted practices for COPVs used in space applications developed as a collaboration of industry, government, and universities. The standard covers many aspects of COPVs including damage tolerance life analyses that are used for flight qualification overseen by fracture control boards. The standard for damage tolerance requires that the COPV “…survive four operational lifetimes with the largest crack in the metallic liner that can be missed by a nondestructive evaluation (NDE) subjected to bounding stresses representative of what the COPV experiences in its life (manufacturing, integration, operational including thermal and residual).” The operational life of a COPV liner typically includes an initial elastic-plastic cycle (autofrettage or proof) followed by other cycles that may be elastic (elastically responding liners) or elastic-plastic (plastically responding liners). A representative load spectrum is shown at right. During autofrettage, the COPV is pressurized to at least proof pressure to compress the liner inner surface, making it less susceptible to operational stresses. COPVs with elastically responding liners may be damage-tolerance qualified using LEFM analysis tools, but plastically responding liners must be damage-tolerance qualified by testing. Guidance on evaluating the appropriateness of LEFM tools for COPV damage tolerance was provided in NESC Technical Bulletin No. 21-04, Evaluating Appropriateness of LEFM Tools for COPV and Metal Pressure Vessel Damage Tolerance Life Verification Tolerance Life Verification and NASA/TM-2020-5006765/Volumes 1/2. 

A COPV consists of a metallic liner with an exterior composite wrap. The composite provides strength, and the liner contains the compressed fluid or gas.
Results of a failure test. COPVs contain high pressure gases or fluids that can have tremendous explosive energy. 

Future of the Structures Discipline 

As the Agency moves more toward forming strategic industry partnerships with commercial contracts for new programs, the Structures TDT has highlighted the need for proper focus on appropriate requirements as the Team’s strategic vector. Although NASA Standards are often provided for reference, their prescriptive nature is not necessarily appropriate for use with commercial contracts. Industry partners and/or NASA team members create alternative standards, unique for each program, but there is inconsistency across different programs with respect to detailed requirements in these standards. Emerging technologies such as soft goods, large-scale deployable structures, inflatables, probabilistic analysis techniques, and additive manufactured hardware all drive unique requirements. The TDT identified the need for a tailoring guide, tied to mission priorities and risk postures, to assist with insight/oversight strategies for NASA programs. Using industry partners also means less NASA-owned hardware, which can lead to a loss of institutional knowledge. 

Representative loading spectrum for an elastically responding COPV liner with an initial elastic-plastic cycle.  

Its imperative that Engineering Directorates at each center proactively look for in-house projects so the next generation of engineers have opportunities for hands-on experience developing, designing, and testing (DDT) flight hardware. This experience is the foundation necessary for NASA engineers to guide the commercial partners through their own DDT processes and to be able to provide appropriate verification and validation of NASA requirements. Structures TDT members form a diverse team crossing all centers and programs, facilitating good collaboration on requirement interpretation, which ultimately ensures safety of NASA crew and mission success of operations in these new commercial programs. 

Computed tomography scan of a metallic liner detecting a part-through crack. 

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Meagan Chappell

Harnessing the 2024 Eclipse for Ionospheric Discovery with HamSCI

Harnessing the 2024 Eclipse for Ionospheric Discovery with HamSCI

3 min read

Harnessing the 2024 Eclipse for Ionospheric Discovery with HamSCI

As the total solar eclipse on April 8, 2024, draws closer, a vibrant community of enthusiastic amateur radio operators, known as “hams,” is gearing up for an exciting project with the Ham Radio Science Citizen Investigation (HamSCI) group. Our goal is clear and ambitious: to use the Moon’s shadow as a natural laboratory to uncover the intricacies of the ionosphere, a layer of Earth’s atmosphere crucial for radio communication.

This rare event offers an unmatched opportunity to observe the ionosphere’s response to the temporary absence of solar radiation during the eclipse. HamSCI, a collective of citizen scientists and professional researchers, plans to seize this opportunity by conducting radio experiments across North America.

The Sun, seen in red with bright orange area, partially covered by black circle coming from the top left – the Moon.
This image captures the Moon passing in front of the Sun during an eclipse on Jan. 30, 2014, seen in space by NASA’s Solar Dynamics Observatory.
NASA/SDO

Our mission centers on two main activities: the Solar Eclipse QSO Party (SEQP) and the Gladstone Signal Spotting Challenge. For the SEQP, amateur radio operators across the continent will aim to establish as many radio contacts (called QSOs) as possible before, during, and after the eclipse, creating a lively scene filled with radio signals. This effort will generate a vast network of observations on radio wave behavior under the eclipse’s unique conditions. The SEQP, a competitive yet friendly event, encourages wide participation and adds an element of excitement.

The Gladstone Signal Spotting Challenge, named in honor of ham radio operator Philip Gladstone for his significant contributions to radio science, adopts a focused approach. Participants will use special equipment to monitor select radio frequencies, aiding in our observation of the ionosphere’s reaction to the eclipse. This crucial aspect of our project validates scientific models of the ionosphere and enriches our understanding of its interaction with solar radiation.

Amateur radio enthusiasts of all backgrounds and skill levels are invited to join these events, united by a shared enthusiasm for scientific exploration and a collective curiosity about the upper atmosphere. Through the support of the amateur radio community, HamSCI demonstrates the profound impact of citizen science in contributing to our scientific knowledge.

As the eclipse ends, our analytical work begins. We will delve into the collected data, interpret it, and publish our findings. These efforts are expected to significantly advance our understanding of the ionosphere and showcase the value of community involvement in scientific discovery.

HamSCI is an organization that aims to inspire wonder and encourage people to participate in scientific discovery. The community of citizen scientists associated with HamSCI believe that the seamless fusion of science and amateur radio is an excellent example of what can be achieved when people come together, driven by curiosity and a passion for exploration.

For more information about HamSCI and details on the SEQP and the Gladstone Signal Spotting Challenge, please visit:

By McKenzie Denton
HamSCI Citizen Science Team Member

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How NASA’s Roman Telescope Will Measure Ages of Stars

How NASA’s Roman Telescope Will Measure Ages of Stars

Guessing your age might be a popular carnival game, but for astronomers it’s a real challenge to determine the ages of stars. Once a star like our Sun has settled into steady nuclear fusion, or the mature phase of its life, it changes little for billions of years. One exception to that rule is the star’s rotation period – how quickly it spins. By measuring the rotation periods of hundreds of thousands of stars, NASA’s Nancy Grace Roman Space Telescope promises to bring new understandings of stellar populations in our Milky Way galaxy after it launches by May 2027.

Stars are born spinning rapidly. However, stars of our Sun’s mass or smaller will gradually slow down over billions of years. That slowdown is caused by interactions between a stream of charged particles known as the stellar wind and the star’s own magnetic field. The interactions remove angular momentum, causing the star to spin more slowly, much like an ice skater will slow down when they extend their arms.

This effect, called magnetic braking, varies depending on the strength of the star’s magnetic field. Faster-spinning stars have stronger magnetic fields, which causes them to slow down more rapidly. Due to the influence of these magnetic fields, after about one billion years stars of the same mass and age will spin at the same rate. Therefore, if you know a star’s mass and rotation rate, you potentially can estimate its age. By knowing the ages of a large population of stars, we can study how our galaxy formed and evolved over time.

Measuring Stellar Rotation

How do astronomers measure the rotation rate of a distant star? They look for changes in the star’s brightness due to starspots. Starspots, like sunspots on our Sun, are cooler, darker patches on a star’s surface. When a starspot is in view, the star will be slightly dimmer than when the spot is on the far side of the star.

Image of the Sun with sunspots
This image of our Sun was taken in August 2012 by NASA’s Solar Dynamics Observatory. It shows a number of sunspots. Other stars also experience starspots, which cause the star’s observed brightness to vary as the spots rotate in and out of view. By measuring those changes in brightness, astronomers can infer the star’s rotation period. NASA’s Nancy Grace Roman Space Telescope will collect brightness measurements for hundreds of thousands of stars located in the direction of the center of our Milky Way galaxy, yielding information about their rotation rates.
Credit: NASA

If a star has a single, large spot on it, it would experience a regular pattern of dimming and brightening as the spot rotated in and out of view. (This dimming can be differentiated from a similar effect caused by a transiting exoplanet.) But a star can have dozens of spots scattered across its surface at any one time, and those spots vary over time, making it much more difficult to tease out periodic signals of dimming from the star’s rotation.

Applying Artificial Intelligence

A team of astronomers at the University of Florida is developing new techniques to extract a rotation period from measurements of a star’s brightness over time, through a program funded by NASA’s Nancy Grace Roman Space Telescope project.

They are using a type of artificial intelligence known as a convolutional neural network to analyze light curves, or plots of a star’s brightness over time. To do this, the neural network first must be trained on simulated light curves. University of Florida postdoctoral associate Zachary Claytor, the science principal investigator on the project, wrote a program called “butterpy” to generate such light curves.

A graph labeled “Simulated Star, Light Curve with Starspots.”
A star can have dozens of spots scattered across its surface at any one time, causing irregular brightness fluctuations that make it difficult to tease out periodic signals of dimming due to the star’s rotation. This graph of data from the butterpy program shows how the observed brightness of a simulated star would vary over a single rotation period. NASA’s Roman Space Telescope will be able to measure the light curves, and therefore rotation rates, of hundreds of thousands of stars, bringing new insights into stellar populations in our galaxy.
Credit: NASA, Ralf Crawford (STScI)

“This program lets the user set a number of variables, like the star’s rotation rate, the number of spots, and spot lifetimes. Then it will calculate how spots emerge, evolve, and decay as the star rotates and convert that spot evolution to a light curve – what we would measure from a distance,” explained Claytor.

The team has already applied their trained neural network to data from NASA’s TESS (Transiting Exoplanet Survey Satellite). Systematic effects make it more challenging to accurately measure longer stellar rotation periods, yet the team’s trained neural network was able to accurately measure these longer rotation periods using the TESS data.

Roman’s Star Survey

The upcoming Roman Space Telescope will gather data from hundreds of millions of stars through its Galactic Bulge Time Domain Survey, one of three core community surveys it will conduct. Roman will look toward our galaxy’s center – a region crowded with stars – to measure how many of these stars change in brightness over time. These measurements will enable multiple science investigations, from searching for distant exoplanets to determining the stars’ rotation rates.

The specific survey design is still being developed by the astronomical community. The NASA-funded study on stellar rotation promises to help inform potential survey strategies.

“We can test which things matter and what we can pull out of the Roman data depending on different survey strategies. So when we actually get the data, we’ll already have a plan,” said Jamie Tayar, assistant professor of astronomy at the University of Florida and the program’s principal investigator.

“We have a lot of the tools already, and we think they can be adapted to Roman,” she added.

The Nancy Grace Roman Space Telescope is managed at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, with participation by NASA’s Jet Propulsion Laboratory and Caltech/IPAC in Southern California, the Space Telescope Science Institute in Baltimore, and a science team comprising scientists from various research institutions. The primary industrial partners are BAE Systems, Inc. in Boulder, Colorado; L3Harris Technologies in Melbourne, Florida; and Teledyne Scientific & Imaging in Thousand Oaks, California.

By Christine Pulliam
Space Telescope Science Institute, Baltimore, Md.

​​Media Contact:
Claire Andreoli
NASA’s Goddard Space Flight Center, Greenbelt, Md.
301-286-1940

Christine Pulliam
Space Telescope Science Institute, Baltimore, Md.

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Ashley Balzer