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The Expedition 55 crew members are packing up the SpaceX Dragon cargo craft today for its return to Earth on Wednesday. Meanwhile, the six International Space Station residents continue operating a multitude of space experiments while ensuring the orbital lab remains in tip-top shape.

NASA astronauts Scott Tingle and Ricky Arnold transferred an array of biological samples from station science freezers to specialized freezers stowed inside Dragon. The research samples are for analysis by scientists and are among a variety of cargo, including station hardware for refurbishment, returning to Earth inside Dragon Wednesday.

NASA TV begins its live coverage of the Dragon departure at 10 a.m. EDT on Wednesday. Robotics controllers on the ground will command the Canadarm2 to release Dragon at 10:22 a.m. Tingle will be in the Cupola monitoring the release and departure activities. Dragon will fire its engines for the final time at 3:06 p.m. beginning its descent back into Earth’s atmosphere before splashing down in the Pacific Ocean around 4 p.m. NASA TV will not cover Dragon’s splashdown about 260 miles southwest of Long Beach, Calif.

Flight Engineer Drew Feustel tended to a variety of experiment hardware today supporting life science and biomedical research. He spent the morning working on the Multi-Use Variable-G Platform that houses tiny organisms such as fruit flies, flatworms, plants, fish and cells. Feustel then configured the Human Research Facility-2 with gear enabling ongoing observations of the physical and mental changes taking place in astronauts living in space.

Robotics controllers and Expedition 55 crew members are getting ready for the departure of the SpaceX Dragon resupply ship next week. The commercial space freighter will leave the International Space Station and splashdown in the Pacific Ocean on Wednesday loaded with cargo for retrieval and analysis.

Flight Engineer Ricky Arnold powered up command and communications gear today that will aid the crew when Dragon departs the station on Wednesday at 10:22 a.m. EDT. NASA TV will begin its live coverage of the departure activities at 10 a.m. Dragon will splashdown in the Pacific Ocean about six hours later to be recovered by SpaceX and NASA personnel. The splashdown off the southern coast of California will not be seen on NASA TV.

The Canadarm2 will be remotely maneuvered today to grapple Dragon today while it is still attached to the Harmony module. In the meantime the 57.7-foot-long robotic arm and its fine-tuned robotic hand, also known as Dextre, are completing the installation of an external materials exposure experiment outside of Japan’s Kibo laboratory module.

Astronauts Drew Feustel and Scott Tingle are still packing Dragon today with a variety of cargo including space station hardware and research samples. The STaARS-1 experiment facility has completed a year of operations at the station and is being readied for its return aboard Dragon next week. The research device supported observations of living systems exposed to simulated gravity such as Earth, the Moon and Mars. Feustel also stowed faulty life support gear in Dragon for refurbishment back on Earth.